Endothelial mitochondrial transfer and vascular health
Mitochondrial transfer is a newly recognized form of intercellular communication that supports endothelial function and vascular health.
Mitochondrial dysfunction drives endothelial pathology, contributing to impaired vascular function, inflammation, and metabolic dysregulation.
Endothelial cells acquire mitochondria via tunneling nanotubes (TNTs) and extracellular vesicles (EVs), enhancing resilience under stress and promoting vascular repair.
Beyond energy production, mitochondria regulate reactive oxygen species (ROS) signaling, immune responses, and mechanotransduction, which are critical for endothelial integrity.
Mitochondrial transplantation is emerging as a therapeutic strategy to counteract vascular aging, ischemia, and inflammation.
Challenges remain in optimizing mitochondrial delivery, ensuring functional integration, and translating mitochondrial therapies into clinical practice.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00105-9
