A neuroactive peptide identified from long non-coding RNA in motor neurons
Long noncoding RNA, lncMN3 is conserved between humans and mice and predominantly expressed in motor neurons and shows potential coding capabilities and is associated with polysomes.
The authors identified SERTM2 micropeptide generated from lncMN3 in motor neuron membranes that modulates their excitability, contributing to the establishment of the membrane resting potential.
In-silico modeling, co-immunoprecipitation, and immunofluorescence demonstrate that SERTM2 interacts with the TASK1 potassium channel, highlighting its key role in motor neuronal function.
https://www.embopress.org/doi/full/10.1038/s44319-025-00404-w
