Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits
The researchers present a collection of precision viral genetic tools for targeting and perturbing major striatal neuronal populations in rodents and primates.
AAV toolbox enables precise labeling of major striatal neuron subclasses. Enhancer AAVs achieve ≥90% cell-type specificity across multiple modalities.
These tools will facilitate multiple applications including optogenetic circuit dissection, comparative cellular analyses across species, disease modeling, and development of novel AAV gene therapy approaches.
