Astrocyte-microglia crosstalk in stroke!

Astrocytes form borders and act as physical barriers following central nervous system injury.

Evidence suggests that astrocytes regulate inflammation and repair but their characteristics at the border sites and interactions with immune cells are not well understood.

The researchers in this study reveal that bone marrow stromal cell antigen 2 (BST2)-positive border astrocytes regulate astrocyte-microglia interactions via C3/C3aR signaling after stroke.

Genetic or antibody blockade of BST2 reduces these interactions and improves early functional outcomes, highlighting BST2 as a therapeutic target for brain repair.

https://www.cell.com/neuron/fulltext/S0896-6273(25)00751-2

https://sciencemission.com/BST2-expression-at-astrocyte-borders