Exogenous IL-22 administration resolves MASLD

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Exogenous IL-22 administration resolves MASLD

Consumption of energy-dense diets leads to metabolic dysfunction-associated steatotic liver disease (MASLD).

Defective interleukin-22 (IL-22) signaling has been linked to obesity, diabetes, “gut-liver axis” alterations leading to MASLD pathogenesis.

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The researchers find that exogenously administered IL-22 resolved MASLD mainly by engaging its intestinal epithelial cells receptor (IL22Ra1), rather than hepatocyte receptors.

 The authors also show that activation of STAT3 and inhibition of WNT-β-catenin signaling leads to restoration of diet perturbed intestinal homeostasis.

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00364-4

https://sciencemission.ayurmatrika.com/IL-22-resolves-MASLD-via-enterocyte-STAT3-restoration-of-diet-perturbed-intestinal-homeostasis