FerroTerminator1 as a potent therapeutic drug for MASH
The researchers discover that excess hepatic iron accelerates MASH progression primarily via c-Myc-Acsl4-triggered ferroptosis.
Targeting hepatic iron overload and ferroptosis with FerroTerminator 1 (FOT1) reverses liver injury across multiple MASH mouse models.
Researchers also demonstrate that serum ferritin levels might serve as a predictive biomarker for effective FOT1-based therapy for future clinical trials in MASH.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00284-5
