Thiol-based redox regulation drives fungal pathogenesis
Thiol-based redox regulation plays diverse roles in fungal stress responses, enzyme structure/function, cell signaling, survival, and proliferation.
Thiol redox systems play dual roles in mitigating endogenous reactive oxygen species (ROS) generated via aerobic respiration and combating external stress, such as host-imposed radical species that must be mitigated by fungal pathogens to cause disease.
Glutathione and other small-molecule thiols such as ergothioneine have direct and indirect modulatory roles in redox homeostasis, virulence factor elaboration, and the response to antifungal drugs.
Thiol-based redox systems are critical for fungal pathogenesis and therefore warrant further investigation for antifungal drug development.
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(25)00179-9
