Ferroptosis in pancreatic cancer
Iron accumulation and lipid peroxidation may lead to regulated cell death ferroptosis.
Ferroptosis influences immune remodeling and the tumor microenvironment and related genes and pathways could used as potential biomarkers for cancer risk stratification, treatment prediction, and imaging-based assessment.
Ferroptosis inducers, and inhibitors, could be used as therapeutics for various cancers including pancreatic cancer.
The researchers in this review discuss mechanistic and translational advances, highlighting ferroptosis as a conceptual bridge between cellular metabolism and tumor therapy, and outlining perspectives for precision diagnostics and personalized interventions.
https://link.springer.com/article/10.1186/s12943-025-02567-5
