Fusion oncoprotein condensates in leukemia

Many fusion oncoproteins (and other genetic drivers) in leukemia localize in condensates formed via phase separation. 

Fusion oncoprotein-associated condensates play key roles in leukemic transformation, often via their impact on chromatin state and transcriptional regulation.

Agents that alter the integrity, composition, and/or material properties of condensates represent potential treatments for fusion-driven cancers.

https://www.cell.com/trends/cancer/fulltext/S2405-8033(26)00085-3

https://sciencemission.com/Condensates-in-fusion-oncoprotein-driven-leukemia