A user-friendly tool for brain lipid dyshomeostasis in neurodegenerative diseases
Lipid alterations in the brain have been implicated in many neurodegenerative diseases. To facilitate comparative lipidomic research across brain diseases, we establish a data common
The researchers developed a lipid atlas of the brain named the Neurolipid Atlas. They prepopulated it with isogenic induced pluripotent stem cell (iPS cell)-derived lipidomics data for different brain diseases.
The authors show that iPS cell-derived neurons, microglia and astrocytes exhibit distinct lipid profiles. For example, the Alzheimer disease (AD) risk gene ApoE4 drives cholesterol ester (CE) accumulation specifically in human astrocytes and whole-brain lipidomics from persons with AD showed similar CE accumulation.
They also demonstrate that altered cholesterol metabolism has a major role in astrocyte immune pathways such as the immunoproteasome and major histocompatibility complex class I antigen presentation.
