GABAergic synapse diversity in the brain!
GABAergic synapses contain an elaborate organizational protein machinery with a key role in regulating the properties of GABAergic synaptic transmission.
Recent methodological advances in imaging, electrophysiology, transcriptomics, and proteomics have enabled many new components of this organizational machinery to be identified.
Connection-specific analyses show that these GABAergic synapse organizer proteins are not distributed homogeneously, but that different GABAergic neuron subtypes utilize different molecular components at their synapses.
The resulting diversity of GABAergic organizer complexes offers a unique opportunity for the development of circuit-specific GABAergic therapeutics, although substantial further investigation will be necessary to translate these findings into clinical applications.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(24)00229-7
