Glioblastoma microenvironment complexity
The ability to understand molecular differences at a single cell level, and with increasing granularity, through spatial profiling is starting to unravel the complexity of the glioblastoma tuThemesmor microenvironment (TME).
Identifying variations in the spatial distribution of different cell types is providing novel insights into tumor biology and leading to the identification of TME-based tumor subtypes.
Greater understanding of the relationships between different cell types, and the identification of rare, but biologically important, cell states is identifying new biomarkers for predicting an individual’s response to treatment and suggesting novel resistance mechanisms.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00014-0
