Geroprotective role for vitamin C
female reproductive health is directly related to ovarian aging but pharmaceutical agent that mitigate primate ovarian aging remains largely unexplored.
The researchers demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles.
The authors show that vitamin C can reduce the biological age of oocytes by 1.35 years and somatic cells by 5.66 years.
These geroprotective effects are partially mediated through NRF2 pathway activation, supporting vitamin C as a translatable nutritional strategy to combat reproductive aging.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00339-X
