Glycosylation in cancer metabolism and stemness

Aberrant glycosylation is a hallmark of tumorigenesis primarily due to its influence on the functional features of cancer cells.

Targeting specific types of glycosylation patterns enhances antitumor immunity and significantly reduces tumor progression.

Altered glycan structures influence different metabolic pathways, which then modulate the stem-like properties of cancer cells.

The surprising intersection of glycosylation and RNA suggests new regulatory mechanisms and functional roles of glycosylation.

The convergent understanding of glycomics with other multi-omics analyses will provide new insights into novel functions of glycans in biological systems.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00206-X

https://sciencemission.com/Sugar-symphony:-glycosylation-in-cancer-metabolism-and-stemness