A cortico-subcortical loop for motor control
Neuronal circuits, cortex-basal ganglia (BG)-thalamus loop control movement and locomotion. In addition, the BG directly control movement via specialized connections with the brainstem along with the inhibition of thalamus. It is not clear is other parallel loops exist to control movement.
The researchers reveal a cortico-brainstem- thalamic circuit that controls motor activity.
Glycinergic PRF neurons (GlyT2+) receive motor cortical inputs, which also target the thalamus and the basal ganglia, forming a regulatory loop.
In turn, GlyT2+ PRF neurons inhibit the ipsilateral thalamus and medulla and drive contralateral turning.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00001-4
https://sciencemission.com/cortico-subcortical-loop-for-motor-control
