Antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration
Antimicrobial peptides (AMPs) are key effector molecules in innate immunity, both systemically and locally.
AMPs also play important roles in brain functions such as memory and sleep in the absence of infection.
The expression of many AMPs is increased during aging, neurodegeneration, and brain injuries.
Overactivation of certain AMPs contributes to neuronal cell death in several neurodegenerative disease models.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(24)00173-5
