How brain function impacted by white matter aging

White matter volume reduction, altered structural integrity of myelinated axons, and increased hyperintensities are observed in aging. Brain cognitive decline and neurological disabilities are associated with these changes in white matter. Myelin deterioration

with age further contribute to the progression of neurodegenerative disorders.

The researchers discuss in this review structural alterations in white matter that occur with aging and examine the cellular and molecular mechanisms driving these aging-related transformations.

They also highlight how the progressive disruption of white matter may initiate a self-perpetuating cycle of inflammation and neural damage.

https://www.cell.com/neuron/fulltext/S0896-6273(24)00767-0

https://sciencemission.com/White-matter-aging-and-its-impact-on-brain-function