How extracellular vesicles from neural stem cells protect against intracerebral hemorrhage
Neural stem cell (NSC) derived extracellular vesicles (Evs) use in treating neurological disorders is poorly understood.
The researchers demonstrate that EVs-NSC attenuate neurotoxic astrocyte activation in mice with intracerebral hemorrhage (ICH) and in human astrocyte models.
They identify IFNb as a key driver of neurotoxic astrocytes and show that miR-124-3p within EVs-NSC reduces astrocyte-mediated neurotoxicity by simultaneously degrading IFNb mRNA and inhibiting ELOVL1 expression. This dual action likely reduces astrocyte neurotoxicity by lowering saturated lipid secretion, offering a promising ICH therapy.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01205-1
