How obesity can change identity of brain neurons?

Advances in single-cell transcriptomic tools are reshaping our understanding of how neuronal functional identity is regulated in the mammalian brain throughout the lifespan. 

Mature selected brain neurons in the adult brain express functional identity gatekeepers and may be susceptible to losing or changing their post-embryonic identity.

In mouse models of adult-onset obesity, maladaptive shifts in cell identity regulation are observed in peripheral metabolic organs as well as in brain neurons involved in energy homeostasis.

Obesity is associated with neurodegenerative diseases characterized by impaired maintenance of neuronal identity, such as Alzheimer’s disease.

Unraveling the neurological basis of obesity may shed light on forms of maladaptive neuronal plasticity at the interface of metabolic and neurodegenerative disorders.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00297-2

https://sciencemission.com/Can-brain-neurons-change-identity-Lessons-from-obesity