Long-chain fatty acid oxidation affects hematopoietic stem cells in aged mice
The researchers show that long-chain fatty acid oxidation has context dependent effects on hematopoietic stem cells (HSCs).
It is dispensable for HSC function in young mice.
It becomes necessary for normal HSC function and hematopoiesis in older mice.
A high-fat diet increases fatty acid oxidation, and this impairs HSC function.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00413-2
