How skin inflammation controlled?
It is unclear why the surface of the skin, which constantly encounters proinflammatory stimuli, is not always inflamed.
Researchers have identified a new mechanism underlying inflammatory skin diseases, such as psoriasis and seborrheic dermatitis.
They found that a protein essential in forming the skin’s protective barrier (ZNF750) also plays a role in controlling inflammation in skin cells, shedding light on why some people are more susceptible to inflammatory skin diseases than others.
The researchers show that as differentiated keratinocytes migrate toward the surface of the skin, they turn off the expression of pattern recognition receptors through the activities of ZNF750 and KDM1A.
The study paves the way for more effective and personalized therapies for these debilitating diseases and also offers broader insights into the molecular biology of skin cells.
https://www.cell.com/immunity/fulltext/S1074-7613(24)00446-1
