Immune responses to the rabies vaccine alters with gut microbiome perturbation
In this study, the researchers use a systems vaccinology approach to show that antibiotic-induced microbiome disruption significantly alters the primary vaccine responses in humans.
The authors show that antibiotic administration reduced the gut bacterial load and induced an enhanced pro-inflammatory signature early after vaccination, a shift in the balance of vaccine-specific T-helper 1 (Th1) to T-follicular-helper response toward Th1 phenotype, and profound alterations in metabolites, particularly in secondary bile acids in the blood.
These findings provide insights into microbiome-immune interactions and highlight potential avenues for optimizing vaccine efficacy.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00126-X
