Interplay between circadian dysfunction and Parkinson's disease
A growing body of evidence indicates that circadian disruption is frequently comorbid with Parkinson's disease (PD).
Circadian disruption can occur at different stages during PD progression, and PD subtypes may exhibit distinct types of circadian disruption.
PD models in both vertebrates and invertebrates have been shown to exhibit circadian disruption.
Experimental circadian disruption, either by environmental manipulation or clock gene mutations, has been shown to cause or exacerbate dopamine neuron degeneration.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(24)00203-0
