Mechanism of cellular stress induced neurodegeneration

Cellular stress may contribute to neurodegeneration.

The researchers demonstrate that stress-induced nuclear condensation of the neurodegeneration linked TDP-43 protein causes its transient inactivation and loss of function in splicing.

Although these changes are reversible, some TDP-43 splicing targets, e.g., STMN2, recover slowly, rendering them prone to misregulation under chronic stress.

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00750-2

https://sciencemission.ayurmatrika.com/Stress-induced-TDP-43-nuclear-condensation-causes-splicing-loss-of-function-and-STMN2-depletion