MDM4 exon skipping upon dysfunctional ribosome assembly

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MDM4 exon skipping upon dysfunctional ribosome assembly

Recent studies revealed how nucleolar stress enhances MDM4 exon skipping and activates p53 via the ribosomal protein L22 (RPL22; eL22).

Tumor-associated L22 mutations lead to full-length MDM4 synthesis, overcoming tumor suppression by p53.

This article explores how MDM4 splicing patterns integrate stress signaling to take p53-dependent cell fate decisions.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00212-5

https://sciencemission.com/MDM4-exon-skipping-upon-dysfunctional-ribosome-assembly