MDM4 exon skipping upon dysfunctional ribosome assembly
Recent studies revealed how nucleolar stress enhances MDM4 exon skipping and activates p53 via the ribosomal protein L22 (RPL22; eL22).
Tumor-associated L22 mutations lead to full-length MDM4 synthesis, overcoming tumor suppression by p53.
This article explores how MDM4 splicing patterns integrate stress signaling to take p53-dependent cell fate decisions.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00212-5
https://sciencemission.com/MDM4-exon-skipping-upon-dysfunctional-ribosome-assembly
