Macromolecular assemblies in promoting cellular shutdown in heat
Heat shock (HS) promotes the synthesis of heat shock proteins (HSPs) and represses the synthesis of housekeeping proteins. These processes coincide with the formation of macromolecular assemblies.
In yeast, nuclear export and translation factors associate into functionally arrested macromolecular assemblies that repress the expression of housekeeping mRNAs.
Translation factors undergo HS-induced structural rearrangements in thermolabile domains that strengthen preexisting interactions with other factors, promote macromolecular assembly, and repress the synthesis of housekeeping proteins.
Macromolecular assembly driven by structural rearrangements appears to be a widespread response to stress in yeast. Similar HS-induced mechanisms may be conserved from yeast to humans.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(24)00225-1
