MicroRNA regulation in single cells
MicroRNA (miRNA)-mediated RNA regulation is an important cellular process that leads to cellular heterogeneity.
New single-cell sequencing technologies can capture the abundances of small RNA molecules and their sequence variations in individual cells.
Computational approaches for single cell analyses allow investigation of miRNA abundance, miRNA isoform (isomiR) variation, and miRNA targets using existing assays.
Computational integration of different sequence modalities from single cells allows miRNA regulation of gene expression variability and biological processes to be studied.
https://www.cell.com/trends/genetics/fulltext/S0168-9525(24)00317-2
