Ubiquitin-dependent translation control mechanisms
Protein synthesis and degradation is tightly controlled with multiple layers of regulation under optimal conditions and mediate responses to acute environmental challenges.
Studies indicate that protein ubiquitylation events act as molecular signals to specify quality control pathway outcomes.
The researchers here discuss ubiquitin-mediated translation control mechanisms that regulate ribosome-associated quality control pathways at several steps in the translation cycle.
They also discuss how defects in specific ubiquitin-mediated regulatory steps impact physiology and health.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01401-3
