Suppressing glioblastoma!

The researchers report that GBM resists the antipsychotic drug pimozide treatment by activating SREBP-1, which unexpectedly elevates glutamine consumption by upregulating the expression of ASCT2.

They demonstrate combining pimozide with a pharmacological blockade of glutamine consumption effectively inhibits GBM growth in vivo, presenting a promising avenue for targeting GBM.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00427-0

https://sciencemission.ayurmatrika.com/Combinatorial-targeting-of-glutamine-metabolism-and-lysosomal-based-lipid-metabolism-effectively-suppresses-glioblastoma