Mechanisms governing lineage plasticity and metabolic reprogramming in cancer
It is believed that lineage plasticity results in the phenotypic changes in the cancer and concurrent changes in the metabolism that facilitate adaptation to various stressors.
Certain metabolites also serve as synthetic reservoirs for chromatin modification, thus linking metabolic states with epigenetic regulation. Thus, therapies targeting metabolic pathways reduce lineage variation.
This review discusses the interplay between lineage plasticity and metabolic reprogramming to prevent the emergence of lethal disease.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(24)00168-7
