Extrachromosomal DNA in cancer
This review discusses open questions on the evolutionary role of extrachromosomal DNA (ecDNA) in tumor development, including tumorigenesis and metastatic seeding.
The author discuss the mutational landscape on ecDNA, the dynamic ecDNA genotype– phenotype map, the structural evolution of ecDNA, and how knowledge of tissue-specific ecDNA evolutionary paths can be leveraged to deliver more effective clinical treatment.
They also describe how evolutionary theoretical modeling will be instrumental in advancing new research in the field, and we explore how modeling has contributed to our understanding of the evolutionary principles governing ecDNA dynamics.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00146-3
