Mechanisms shaping pancreatic islet morphogenesis
Models of islet morphogenesis differ in the extent of endocrine cell migration and self-segregation. Pancreatic niche signals guide endocrine cell differentiation and morphogenesis.
Extrinsic signaling cues play critical roles in shaping 3D islet architecture and morphogenesis.
Distinct congenital disorders impairing islet morphogenesis provide insight into the mechanisms governing islet development and function.
Understanding 3D islet morphogenesis can lead to improved stem cell-derived islet products for regenerative therapy.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(26)00100-1
