How acarbose protects against diet-induced obesity
Acarbose (ACA) is an alpha-glucosidase inhibitor that has been used to alleviate obesity-induced insulin resistance and type 2 diabetes but the mechanism remains unclear.
Inflammation has been linked to obesity and obesity-induced insulin resistance (IR).
The researchers identify that acarbose enhances the abundance of propionic acid producing Parasutterella, therefore indirectly inhibiting M1-like adipose tissue macrophages (ATMs) via GPR43 in diet-induced obese mice.
Meanwhile, acarbose directly inhibits M1-like ATM proinflammation through GPR120, thus leading to a reduction in adipose tissue inflammation overall.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00654-2
https://sciencemission.com/acarbose-in-diet--induced-obesity
