Mesoscale tissue states in fibrosis
Two decades of molecular dissection have defined key signalling pathways driving fibrosis, yet approved antifibrotic therapies slow functional decline without durably arresting disease progression or restoring tissue architecture.
Despite recent advances in single-cell and spatial biology, how molecular and cellular states are organised to govern tissue-level disease persistence in fibrosis remains poorly understood.
Mesoscale tissue organisation represents an intermediate level of biological organisation in which coordinated interactions between cells, extracellular matrix, and tissue architecture generate emergent tissue behavior.
Mesoscale biology provides a framework for integrating the molecular, spatial, and mechanical determinants of tissue behaviour across biological scales.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(26)00257-1
