The peripheral neuroimmune system
While immune system provides protection against injury and infection through inflammation, the nervous system relays signals between the body and the brain by processing sensory inputs and executing motor outputs.
Recent evidence the peripheral nervous system acts in concert with the immune system to control reflexes that maintain and restore homeostasis. The cholinergic anti-inflammatory pathway defines a neuroimmune circuit by which the autonomic nervous system regulates systemic inflammation.
Itch neuroimmunology has revealed that there are shared signaling pathways between sensory neurons and immune cells, suggesting that there is evolutionarily conserved crosstalk across the nervous and immune systems.
Dysregulation of these neuroimmune interactions may underlie various pathological conditions.
How these two distinct systems communicate is an emerging field of peripheral neuroimmunology and may help in development of various therapeutics and treating diseases.
https://academic.oup.com/jleukbio/article/116/6/1291/7826163
https://sciencemission.com/The-peripheral-neuroimmune-system
