Microbiota–neuroepithelial signalling across the gut–brain axis
Gut microbiota is known to modulate brain activity and behavior. Brain signals can also influence the composition and function of the gut microbiota. This bidirectional communication across
Intimate connections between chemosensory epithelial cells and sensory nerve fibres, that conveys interoceptive signals to the central nervous system act as mediators of the gut microbiota–brain axis.
The authors in this Review, provide an outline of the pathways that connect the gut and the brain, and the signals that are transmitted between microorganisms and neurons at the intestinal neuroepithelial interface.
The authors also discuss the mechanisms that govern gut microbiota–brain interactions and their implications for gastrointestinal and neuropsychiatric health.
