Molecular circuits for genomic recording of cellular events
Traditional genetic reporters are useful but transient and challenging to scale.
CRISPR-based genomic recordings encode cell states and signals as stable DNA edits.
Prime editing enables multiplexed, temporally resolved genomic recordings.
De novo-designed protein sensors may expand the available cell states and signals for recording.
https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00079-4
https://sciencemission.com/genomic-recording-of-cellular-events
