Microglia-based cell therapies for the treatment of neurodegenerative diseases
Onset and progression of various neurodegenerative diseases have been linked to microglia and might be promising cell type for targeted therapeutic interventions.
This review discuss the microglia focused strategies for the treatment of diverse neurodegenerative disorders including lysosomal storage disorders, granulin frontotemporal dementia, and Alzheimer’s disease.
These include replacing faulty microglia with peripheral macrophage precursors or induced human pluripotent stem cell–derived microglia to engineering microglia that target toxic aggregates or deliver remediating payloads.
The authors also look into the potential limitations as well as the clinical benefits of these strategies.
https://www.sciencedirect.com/science/article/pii/S0952791525000287
