A neuronal Slit1 in myelination under chronic hypoxic conditions
Hypoxia-induced oligodendrocyte maturation arrest results in white matter injury (WMI) and long-term neurofunctional disabilities of preterm infants but the role of neurons is not clear.
The researchers demonstrate that upregulated Slit1 from neurons is required for white matter integrity in neonatal hypoxic mice. They show that neuronal Slit1-dependent signaling in protecting against hypoxia-induced hypomyelination and ameliorating motor and cognitive disabilities.
They find that secreted Slit1 promotes oligodendrocyte differentiation via activating Robo2-srGAP1-RhoA signaling axis in oligodendrocyte and hypoxia-induced hypomyelination can be rescued by RhoA inhibitor.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00238-4
