Myelin remodeling via neurotransmitter-activated GPCR signaling

Myelin plasticity is an intrinsic property of mature myelin, enabling activity dependent remodeling of myelin sheaths by oligodendrocytes. 

Because myelin is dynamically remodeled, changes in sheath thickness, compaction, and internode length can influence axonal function and neuronal health.

Neurotransmitters regulate oligodendrocyte biology through ionotropic and metabotropic receptors, linking neuronal activity to myelin remodeling.

G protein-coupled receptors expressed by oligodendrocyte lineage cells integrate neurotransmitter signals and represent promising targets to modulate myelin turnover and promote remyelination.

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(26)00087-0

https://sciencemission.com/GPCR-signaling-in-myelin-plasticity