Schwann cell role in peripheral nerve degeneration after neurotrauma
Neurotrauma in limbs can induce sustained neuroinflammation, resulting in the retardation of axon regrowth.
The researchers reveal that Schwann cell derived sFRP1 binds to HSP90 in macrophages, thus triggering a dysregulated secretion of inflammatory mediators.
Human injured peripheral nerves reveals the appearance of sFRP1-expressing SCs with mesenchymal traits and macrophages with a proinflammatory genetic profile.
Functional blockade of sFRP1 or deletion of macrophage-specific HSP90 alleviates neuroinflammation and prevents the progression of nerve degeneration.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00538-X
