Inhibiting calcium channel TRPC6 to prevent breast cancer cell metastasis

The researchers in this study evaluated the role of transient receptor potential cation channel 6 (TRPC6) in enabling breast cancer cells to resist stimuli that induce ferroptosis.

The authors show that triple-negative breast cancer (TNBC) cell lines exhibit increased TRPC6 expression and resistance to ferroptosis compared to proliferating cells. 

They report that the calcium channel TRPC6 enables TNBC cells to evade ferroptosis by repressing c-Myc to sustain glutathione (GSH) levels. Treatment of TNBC cells with a TRPC6 inhibitor reduces metastasis significantly, an effect that is mitigated by a ferroptosis inhibitor. 

Thus, TRPC6 channel has a causal role in metastasis, and its targeted inhibition impedes metastasis by inducing ferroptosis.

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01314-2

https://sciencemission.com/impede-metastasis-by-inhibiting-TRPC6