Neuronal activity-dependent gene regulation

Genetically determined cis-elements, promoters, and enhancers, are the first requirement of activity-dependent gene expression. 

Chromatin states are pre-prepared at the activity-dependent gene sites before the elevation of neuronal activity but are further modified by neuronal activity.

Neuronal activity promotes transcription factor (TF) binding to cis-elements by increasing the binding time and/or the repetition of binding and dissociation.

TF activation and increased TF concentrations are likely necessary and sufficient for activity-dependent gene regulation.

https://www.cell.com/trends/genetics/fulltext/S0168-9525(24)00316-0

https://sciencemission.com/neuronal-activity-dependent-gene-regulation