Gene circuits for longevity
Systems-level approaches complement static insights by revealing how gene regulatory networks (GRNs) dynamically regulate cellular aging and promote longevity.
Observing the dynamics of heme biosynthesis and nucleolar silencing in budding yeast reveals distinct aging modes, and synthetic biology can significantly extend lifespan.
Negative feedback loops in aging related processes such as proteostasis, energy metabolism, and DNA damage response pathways maintain cellular homeostasis and counteract aging related deterioration.
Synthetic biology offers potential interventions to reinforce feedback circuits, thereby mitigating age-related diseases and promoting healthy aging.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00040-6
