Neuronal aging and degeneration from DNA damage
Neuronal functions decline with age and in neurodegenerative diseases and DNA damage is one of the major risk factors implicated.
It is not clearly understood how DNA damage causes neurodegeneration but next-generation sequencing methods have begun to reveal the characteristics of neuronal DNA damage hotspots and the causes of DNA damage.
Alteration in chromatin topology, chromatin organization and defects in DNA repair also affect neuronal function after DNA damage.
In addition, DNA damage-induced inflammation as an important contributor to the age-related decline in neuronal functions.
