Neurosteroid production using gut bacteria and plant-based materials
This study aims to establish a sustainable microbial platform for neurosteroid production, leveraging the inherent stereoselectivity of bacterial enzymes to eliminate costly chiral separations.
Gut bacteria enable stereoselective synthesis of neurosteroid isomers (isopregnanolone, epipregnanolone, and pregnanolone) with over 99% chiral purity.
Sustainable plant biomass-based medium replaces animal-derived components for whole-cell progesterone biotransformation.
Multigram-scale production of progestogenic neurosteroids and one-step open-column purification were established to bypass chiral chromatographic separation.
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(26)00052-1
