Vitamin C inhibits ferro-aging!
Oxidative stress may lead to aging but the mechanism is not well understood.
The researchers in this study identify that an iron-triggered aging pathway. They demonstrate that in humans and non-human primates, iron accumulation in aging fueled by chronic lipid peroxidation orchestrated via acyl-coenzyme A (CoA) synthetase long-chain family member 4 (ACSL4) and promotes cellular senescence and systemic functional decline.
The authors show that vitamin C directly targets and inhibits ACSL4, thereby blocking ferro-aging.
Their further research shows that long-term VC supplementation in in aged monkeys for over 40 months systemically attenuates aging and improves metabolic and neurological function.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00053-7
