Nitro-fatty acids in the development of new cancer therapeutics

 Anti-inflammatory nitro-fatty acids (NO2- FAs) are endogenous and pleiotropic mediators that exert tumor-suppressive effects via a novel mechanism of action by targeting a unique set of tumorigenic target proteins.

NO2-FAs are promising tumor-selective antineoplastic agents with a favorable safety profile demonstrated in several preclinical models of disease and human clinical Phase 1 and 2 trials.

In preclinical models of colorectal and triple-negative breast cancer, NO2-FA exhibited direct anticancer as well as chemo- and radiosensitizing effects in combination with DNA-damaging therapies by suppressing the 26S proteasome, RAD51, and NF-κB.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(24)00208-6

https://sciencemission.com/Nitro-fatty-acids:-promising-agents-for-the-development-of-new-cancer-therapeutics