Nitro-fatty acids in the development of new cancer therapeutics
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NO2-FAs are promising tumor-selective antineoplastic agents with a favorable safety profile demonstrated in several preclinical models of disease and human clinical Phase 1 and 2 trials.
In preclinical models of colorectal and triple-negative breast cancer, NO2-FA exhibited direct anticancer as well as chemo- and radiosensitizing effects in combination with DNA-damaging therapies by suppressing the 26S proteasome, RAD51, and NF-κB.
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(24)00208-6