Subcutaneous fat retention in humans by the Inhibition of basal IL-6 activity

IL-6 receptor blockade in mice and humans result in adipose tissue mass gain. This study investigates whether basal IL-6 activity (resting IL-6 levels) influences fat storage during fasting and postprandial states.

The researchers demonstrate that basal IL-6 activity regulates fat uptake and storage.

IL-6 enhances skeletal muscle fat uptake, promotes fat release from subcutaneous adipose tissue during fasting, and drives the storage of meal-derived fat in subcutaneous tissue.

Whether IL-6 inhibition causes ectopic fat deposition and lipotoxicity remains unclear.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00115-6

https://sciencemission.com/Inhibition-of-basal-IL-6-activity-promotes-subcutaneous-fat