Oligodendrocyte-derived laminin-g1 regulates the blood-brain barrier and CNS myelination in mice
Functional significance of oligodendrocytes (OLs) synthesized laminin-γ1 in the CNS is not known.
Knockout mouse line with laminin-γ1 deficiency in OL lineage cells (γ1-OKO) exhibited weakness/paralysis and die by post-natal day 33.
γ1-OKO develop blood-brain barrier (BBB) disruption in the cortex and striatum via the transcellular, rather than the paracellular, mechanism and regulates oligodendrocyte biology and myelination.
These findings provide strong evidence that non-vascular cell-derived laminin contributes to BBB maintenance and that oligodendrocytes may regulate blood brain barrier integrity and myelination via laminin.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00451-0
