Oligodendrocyte-derived laminin-g1 regulates the blood-brain barrier and CNS myelination in mice

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Oligodendrocyte-derived laminin-g1 regulates the blood-brain barrier and CNS myelination in mice

Functional significance of oligodendrocytes (OLs) synthesized laminin-γ1 in the CNS is not known.

Knockout mouse line with laminin-γ1 deficiency in OL lineage cells (γ1-OKO) exhibited weakness/paralysis and die by post-natal day 33.

γ1-OKO develop blood-brain barrier (BBB) disruption in the cortex and striatum via the transcellular, rather than the paracellular, mechanism and regulates oligodendrocyte biology and myelination.

These findings provide strong evidence that non-vascular cell-derived laminin contributes to BBB maintenance and that oligodendrocytes may regulate blood brain barrier integrity and myelination via laminin.

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00451-0

https://sciencemission.com/Oligodendrocyte-derived-laminin-g1-regulates-the-blood-brain-barrier-and-CNS-myelination-in-mice